May 12, 2010

May 12, 2010
HIV and TB

Welcome to another day in my life. Today is Wednesday and I hope you are having a safe and great week as we make it to the middle of another work week.

It is another beautiful day here in south Florida. We are having a nice breeze every day which helps keep down the heat to a small extent. But considering all the recent tornadoes in Kentucky and other problems, I can not complain about our heat and humidity. I do try to make it to the gym early before the temperatures zoom into the 90s. Plus I prefer working out earlier in the day.

Now reading my blog you hear me take about HIV all the time. But other conditions, like TB, can make living with HIV even harder. I was recently reading a story about people living in NYC with HIV and TB.

The demographics and clinical characteristics of the tuberculosis epidemic amongst patients with HIV in New York City have changed significantly since the advent of antiretroviral therapy.

‘We found significant changes in the sociodemographic and clinical characteristics for both HIV infected and HIV-uninfected tuberculosis patients in NYC, including increases in the proportions with culture negative tuberculosis and with extrapulmonary tuberculosis and decreases in the proportion with multidrug resistant tuberculosis and that died,” write investigators in the June 1st edition of Clinical Infectious Diseases.

The study also showed that the proportion of tuberculosis (TB) patients infected with HIV fell from 60% before 1992 to 22% in the period 2002 to 2005.

Worldwide, TB is the single biggest cause of serious illness and death in people with HIV. Although the impact of the infection is greatest in resource limited settings, TB is one of the most common AIDS defining illnesses in the UK and many other industrialized countries.

Historically, HIV infection, especially when advanced, has been associated with unusual manifestations of TB. But it is unclear if this is still the case since the introduction of effective antiretroviral therapy. Therefore, investigators analyzed the characteristics of the disease in New York City between 1992 and 2005.

This period was divided into three eras: 1992-95 (pre-HIV treatment); 1996 - 2000 (early HIV treatment); 2001 - 2005 (late HIV treatment).

A total of 7224 TB cases were diagnosed in New York between 1992 and 1995, and 60% of these involved patients with HIV.

The total number of diagnosed TB infection fell between 1996 and 2000 to 5933, and only a third of patients were co-infected with HIV.

Further progress was made against the disease after 2001, the total number of cases falling to 3815, with 22% of diagnoses involving patients with HIV.

Over the course of the study there were significant changes in the sociodemographic profile of HIV positive TB patients. The patients become older, and an increasing number of infections involved women. TB diagnoses in individuals infected with HIV heterosexually increased, but the proportion of cases involving injecting drug users fell.

There was also a significant increase in the number of cases involving foreign-born patients (13 to 38%, p < 0.001).

The proportion of patients with extrapulmonary disease only increased from 12% in the pre-treatment era to 18% in the period after 2001 (p < 0.001). In addition, there was an increase in the percentage of patients who had both pulmonary and extrapulmonary disease (from 20 to 28%, p < 0.001)

Closer analysis of this finding showed that the increase in extrapulomary disease only was significant only amongst US-born patients (from 11 to 17%, p < p.001).For disease involving both the lungs and other sites, the increase was only significant for those born outside the US (from 22 to 31%, p < 0.001).

Before 1995, 7% of TB cases in patients with HIV were culture negative. This increased to 21% by 2005. There was a modest fall in the proportion of smear positive case after the introduction of HIV treatment (from 43% before 1995 to 40% in the period 1996 to 2000, p = 0.15).

A significant drop in the proportion of HIV infected patients with multidrug-resistant TB was observed (from 16 to 4%, p < 0.001).

Mortality rates also fell. However, even in the period 2002 to 2005, HIV infected patients with TB still had a higher mortality rate than HIV negative patients (18% vs 3%).

Statistical analysis confirmed the increased risk of extrapumonary disease after HIV treatment was introduced (adjusted odds ratio [AOR] = 1.35; 95% CI, 1.12 to 1.63). It also increased that there was a significant increase in the risk of TB affecting both the lungs and other sites (AOR = 1.79; 95% CI, 1.55 to 2.06).

The investigators’ analysis also showed that the introduction of HIV therapy was accompanied by an increased likelihood of TB being culture negative (AOR = 1.68; 95% CI, 1.38 to 2.04).

Compared to the period before 1995, HIV-positive patients in the early HIV treatment era had a 49% reduction in their risk of dying before TB therapy was initiated, and a 59% reduction in their mortality risk during TB treatment.

“The clinical presentation of tuberculosis has changed substantially in 14 years awareness of these changes may help clinicians diagnose tuberculosis more promptly, especially in HIV infected patients,” write the investigators.

They conclude, “prompt diagnosis of tuberculosis and initiation of treatment is especially important in HIV infected patients, because they continue to experience higher mortality. Future studies should prospectively evaluate the risk of developing tuberculosis and its presentation among HIV- nfected patients with well managed HIV infection and those with poorly controlled disease.”

Just another reason for those of you who are HIV negative to stay that way and for those already infected to be extra vigilant about your health.

Until we meet again; here's wishing you health, hope, happiness and just enough.

big bear hug,

Daddy Dab